John's Story

There is no good age to be diagnosed with Crohn's disease (CD). However, at 19, after a childhood of perfect health and an active lifestyle, I was really scared when my Crohn's struck so hard and so fast.

“After several years of life on hold, I was able to once again pursue my dreams and go back to college”

When the symptoms began, I had massive pain in my gut and blood when I went to the bathroom. Eating became very difficult because food felt like broken glass going through my intestines. I dropped from 165 to 115 pounds in one month. I was 6 foot 3 inches and no longer possessed my tall, athletic build, but rather I was so thin that people began to stare. I felt like I was wearing my disease — a disease no one understood.

When I went to see my physician, he knew right away what it was: Crohn's disease. I was diagnosed in September 1990 and shortly thereafter I underwent two surgeries on my large intestine. My life was on hold — I was not able to work or go to college for four years. Frequent flare-ups prevented even a hint of the normal, active life I had once enjoyed.

My gastroenterologist initially put me on steroids to control the flare-ups, but the side effects were terrible. My hair was falling out, and my face was covered with acne. The side effects got so bad that I decided that the flare-ups from the Crohn's were minor in comparison to taking steroids.

My disease progressively worsened, leading to ten surgeries. I became desperate for a solution that did not include surgery because I just could not endure another hospitalization. I was one step away from losing hope and falling into depression. I was ready to give up.

Finally one of my father's coworkers found information on a biologic therapy treatment while doing research on the Internet. Once I found a gastroenterologist, he started me right away on REMICADE. I had my first treatment in February 2000, which coincided with my 29th birthday. Shortly thereafter I noticed a difference. It was the best birthday present I could have ever received. I was speechless. I had just about given up hope, but with this treatment I felt like I had my life back.

John is representative of patients responding to REMICADE under a physician's supervision. Individual results may vary.

IMPORTANT SAFETY INFORMATION

Only your doctor can recommend a course of treatment after checking your health condition. REMICADE^® (infliximab) can cause serious side effects such as lowering your ability to fight infections. There are reports of serious infections caused by viruses, fungi or bacteria that have spread throughout the body, including tuberculosis (TB) and histoplasmosis. Some of these infections have been fatal. Your doctor should monitor you closely for signs and symptoms of TB during treatment with REMICADE^®.
Unusual cancers have been reported in children and teenage patients taking TNF-blocker medicines. A rare form of fatal lymphoma has occurred mostly in teenage or young adult males with Crohn's disease or ulcerative colitis who were taking REMICADE^® and azathioprine or 6-mercaptopurine. For children and adults taking TNF blockers, including REMICADE^®, the chances of getting lymphoma or other cancers may increase. You should discuss any concerns about your health and medical care with your doctor.

What should I tell my doctor before I take REMICADE^®?

You should let your doctor know if you have or ever had any of the following:

Tuberculosis (TB) or have been near someone who has TB. Your doctor will check you for TB with a skin test. If you have latent (inactive) TB, you will begin TB treatment before you start REMICADE^®.
Lived in a region where certain fungal infections such as histoplasmosis or coccidioidomycosis are common.
Infections that keep coming back, have diabetes or an immune system problem.
Any type of cancer or a risk factor for developing cancer, for example, chronic obstructive pulmonary disease (COPD) or had phototherapy for psoriasis.
Heart failure or any heart condition. Many people with heart failure should not take REMICADE^®.
Hepatitis B virus (HBV) infection or think you may be a carrier of HBV.
Nervous system disorders (such as multiple sclerosis or Guillain-Barré syndrome).

Also tell your doctor about any medications you are taking, including vaccines or Kineret (anakinra), and if you are pregnant, plan to become pregnant or are nursing. Adults and children should not receive a live vaccine while REMICADE^®.

What should I watch for and talk to my doctor about before or while taking REMICADE^®?

The following serious (sometimes fatal) side effects have been reported in people taking REMICADE^®.

You should tell your doctor right away if you have any of the signs listed below:

Infections (such as TB, blood infections, pneumonia)—fever, tiredness, cough, flu, or warm, red or painful skin or any open sores. REMICADE^® can make you more likely to get an infection or make any infection that you have worse.
Lymphoma, or any other cancers in adults and children.
Heart failure—new or worsening symptoms, such as shortness of breath, swelling of your ankles or feet, or sudden weight gain.
Reactivation of HBV—feeling unwell, poor appetite, tiredness, fever, skin rash and/or joint pain.
Liver injury—jaundice (yellow skin and eyes), dark brown urine, right-sided abdominal pain, fever, or severe tiredness.
Blood disorders—fever that doesn't go away, bruising, bleeding or severe paleness.
Nervous system disorders—numbness, weakness, tingling, changes in your vision or seizures.
Allergic reactions during or after the infusion—hives, difficulty breathing, chest pain, high or low blood pressure, swelling of face and hands, and fever or chills.
Lupus-like syndrome—chest discomfort or pain that does not go away, shortness of breath, joint pain, rash on the cheeks or arms that gets worse in the sun. The more common side effects with REMICADE^® are respiratory infections (that may include sinus infections and sore throat), headache, rash, coughing and stomach pain.
Psoriasis—new or worsening psoriasis such as red scaly patches or raised bumps on the skin that are filled with pus.

Medication Guide for REMICADE^®

Please read the Medication Guide for REMICADE^® and discuss it with your doctor.
(Requires Adobe^® Reader^®. Click here to download.)

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

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Last Updated: April 13, 2010